Project 5: AI based modeling of lymphatic cancer progression

Background

To optimally balance the chance of tumor control versus the risk of side effects, local cancer treatment with radiotherapy and surgery rely on accurate definition of the loco-regional extension of the disease on medical images. Most cancers progress through the lymphatic system and form metastases in regional lymph nodes. In this project, we focus on radiotherapy target delineation in head & neck cancer, however, the AI methodology to be developed will be equally applicable to other cancer sites with lymphatic spread.

Working hypothesis

AI methods promise improvements in all steps of head & neck cancer target definition for radiotherapy planning, namely by partially automating target volume delineation, more consistency and less inter-observer variability, and ultimately improvements through more personalized definition of target volumes.

Specific aims for this research project

We address three subproblems that arise in the target delineation process in head & neck cancer, which is illustrated in the figure:

  1. Automatic segmentation of lymph node levels (blue) and individual lymph nodes in CT images (yellow, green), which is currently a labor-intensive manual task.
  2. Improved definition of regional lymph node metastases via better discrimination of healthy and metastatic lymph nodes using radiomic analysis of suspicious lymph nodes (yellow or green).
  3. Development of a personalized model for estimation of the microscopic cancer spread using the methodology of Bayesian network. This will improve the decision which lymph node levels should be included in the target volume treated with radiation.
Head and NEck cancer target volumes